Mesenchymal Stem Cell Therapy for Cardiac Repair
نویسندگان
چکیده
منابع مشابه
Cardiac Stem Cell Therapy for Cardiac Repair
OPINION STATEMENT The discovery of adult cardiac stem cells (CSCs) and their potential to restore functional cardiac tissue has fueled unprecedented interest in recent years. Indeed, stem-cell-based therapies have the potential to transform the treatment and prognosis of heart failure, for they have the potential to eliminate the underlying cause of the disease by reconstituting the damaged hea...
متن کاملStem cell therapy for cardiac repair.
Heart regeneration via stem cell therapy could improve the functional outcome for millions of patients. A goal of cardiac stem cell research is to foster the engraftment of new, beating cardiac cells into the ischemic region of the heart after a myocardial infarction. The key elements of cell therapy for myocardial repair reviewed here are the source of cells and the mechanisms by which these c...
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22 23 24 We recently demonstrated a cardiac therapeutic regimen based on injection of bone 25 marrow mesenchymal stem cells (MSCs) into the skeletal muscle. Although the injected MSCs 26 were trapped in the local musculature, the extracardiac cell delivery approach repaired the 27 failing hamster heart. This finding uncovers a tissue repair mechanism mediated by trophic 28 factors derived from ...
متن کاملStem cell therapy for cardiac repair: benefits and barriers.
Cardiovascular disease remains the leading cause of death worldwide. Acute ischaemic injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately heart failure. Current therapies aim largely to attenuate the pathological remodelling that occurs after injury and to reduce risk factors for cardiovascular disease. Studies in animal models indicate that transplantatio...
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ژورنال
عنوان ژورنال: Current Treatment Options in Cardiovascular Medicine
سال: 2014
ISSN: 1092-8464,1534-3189
DOI: 10.1007/s11936-014-0323-4